BAY 73-1449

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

BAY 73-1449 是一种选择性且有效的前列环素受体拮抗剂（IC50<0.1 nM）。

BAY 73-1449 is a selective and potent antagonist of the prostacyclin receptor(IC50<0.1 nM).(In Vivo):In male Wistar rats, BAY 73-1449 (0.1-1 mg/kg; i.v.) significantly reduced splenic shunt vessel outflow without affecting mesenteric inflow. BAY 73-1449 (1-5 mg/kg; s.c.) has no effects on portal pressures and the degree of porto-systemic shunting in rats.

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BAY 73-1449 (0.1-1 mg/kg; i.v.) does not significantly reduce mesenteric inflow, but significantly reduces splenic shunt vessel outflow in rats.BAY 73-1449 (1-5 mg/kg, s.c. once daily for 7 d) has no effects on the degree of porto-systemic shunting in rats.BAY 73-1449 (1 mg/kg, s.c. once daily for 7 d), has no effects on portal pressures in rats. Animal Model:Male Wistar rats (250-350 g) are ligated portal veinDosage:0.1, 1 mg/kg.Administration:A single i.v.Result:Significantly reduced shunt flow without affecting mesenteric flow.

BAY73-1449 | BAY 73-1449

Others

Other Targets

RhoA| Lbc

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693790-96-4

425.488

C26H23N3O3

>98% (HPLC)

In Vitro:?DMSO : 250 mg/mL (587.57 mM)

OC(=O)[C@H](Cc1ccccc1)Nc1cc(ncn1)-c1ccc(OCc2ccccc2)cc1

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(-20℃)

With Ice Pack

≥ 2 years